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In the development of drugs for the treatment of central nervous system (CNS) disorders, the prediction of human CNS drug action is a big challenge. Besides plasma pharmacokinetics (PK), plasma protein binding, and passive and active transport across the blood-brain barriers (the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB)), processes within the brain can also influence brain target site PK, including bulk flow, diffusion, and extra-intracellular exchange. Each of the different processes that determine drug concentrations at the relevant CNS target has its...

Pension systems are under serious pressure worldwide. This pressure stems not only from the well-known trend of population ageing, but also from those of increasing heterogeneity of the population and increasing labour mobility. The current economic crisis has aggravated these problems, thereby exposing the vulnerability of many pension schemes to macroeconomic shocks. This book reconsiders the multi-pillar pension scheme against the background of these pressures. It adopts an integral perspective and asks how the pension system as a whole contributes to the three basic functions of pension...