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Over the past decade many of the key lymphokines, hormones and growth factors that help regulate the immune system have been defined. These molecules, termed biological response modifiers (BRMs), have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases. Advances in this area have also led to rethinking therapies against a range of autoimmune disorders and other diseases associated with immune and endocrine imbalances....

The 2nd International Symposium on Combination Therapies brought together several hundred of the leading researchers, scientists and clinicians in this area to discuss new and emerging uses for biological response modifiers (BRM's) in the treatment of cancer and infectious diseases. The meeting was held during May 1-3, 1992 in Acireale, Sicily (Italy). It was hosted by Professor G. Nicoletti CU. of Catania) and organized by the Institute for Advanced Studies in Immunology and Aging (Washington, D. C. ) in collaboration with the University of Rome "Tor Vergata," the University of Catania and...

Proceedings of the 2nd International Symposium on Combination Therapies for Cancer held in Sicily (Italy) in May 1992. Papers address the mechanism of action and rationale for use of biological response modifiers (BRM) in the treatment of cancer. BRM's possible role in treating infectious diseases,

Proceedings of the First International Symposium on Combination Therapies, held March 1991, in Washington, D.C. Papers encompass experimental and clinical work, as well as basic research elucidating the ever-widening range of BRMs. Arrangement is in five sections on molecular, cellular, and gene app

Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron- mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol- ume is based on papers presented at the 1986 International Confer- ence on Prostaglandins and Cancer organized...