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The investigation on glutamic acid analogs as possible antineoplastic agents started in the laboratories in the seventies. In continuation of this line of work several substituted amines were prepared and evaluated biologically. The main focus of this reaction work was to synthesize analogs of glutamic acid and look for their better antineoplastic activity. The structure of the synthesized compounds were confirmed and characterized with the help of IR, 1H-NMR, 13C-NMR, Mass spectra and elemental analysis. For the docking we have taken the protein Histone Deacetylase (HDAC) and identified the...

In this book various 2-substituted 4,5-diphenyl imidazoles were prepared by refluxing benzyl with different aromatic aldehydes. The synthesized compounds were characterized by physical data analysis and spectral analysis. The synthesized compounds exhibited analgesic activity against chemically and thermal noxious stimuli. The analgesic activity was found to be significant on the tail-flick model and on the acetic acid induced writhing model. The anti-inflammatory activity was found to be significant on the Carrageenan-induced paw oedema model compared to control. In the Pheretima posthuma,...