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Since the last decade, the paradigm has been shifted to "Green Chemistry" to meet the challenges of sustainable development. It has become the quest and challenge for chemists to develop green reaction process without affecting their efficiency to reduce the environmental impact. Further, it is likely that the green chemistry trend will continue to grow over the next few decades. Interestingly, the Biginelli-sca olds have shown promising value in drug development as they exhibit a wide spectrum of pharmacological activities. During the past years, copious research has been done on...