Minimal Residual Disease Testing: Current Innovations and Future Directions

ISBN-13: 9783319948263 / Angielski / Miękka / 2018 / 197 str.

Druley, Todd E.

Opis

This volume provides a concise yet comprehensive overview of minimal residual disease (MRD) testing. The text reviews the history of MRD testing, MRD testing for acute lymphoblastic leukemia/lymphoma, molecular diagnostics for MRD analysis in hematopoietic malignancies, the use of "difference from normal" flow cytometry in monitoring AML response, ML-DS for measurable residual disease detection, and advancements in next generation sequencing for detecting MRD.Written by experts in the field, Minimal Residual Disease Testing: Current Innovations and Future Directions is a valuable resource for hematologists, oncologists, pathologists, and radiologists on the variety of technologies available to detect MRD and how best to integrate these platforms into clinical practice.

Spis treści

1. Introduction

Nitin Mahajan, Todd Druley

2. Minimal Residual Disease Testing in Acute Lymphoblastic Leukemia/Lymphoma

Laura Wake, Xueyan Chen, Michael J. Borowitz 

3. Molecular Diagnostics for Minimal Residual Disease Analysis in Hematopoietic Malignancies

Barbara K. Zehentner

4. Monitoring AML Response Using “Difference From Normal” Flow Cytometry

Michael R. Loken, Lisa Eidenschink Brodersen, Denise A. Wells

5. ML-DS: A Unique Condition for Measurable Residual Disease Detection 

Elisabeth R. Wilson, R. Spencer Tong

6. Advancements in Next Generation Sequencing for Detecting Minimal Residual Disease

Erin L. Crowgey, Nitin Mahajan

O autorze

Todd E. Druley, MD, PhD

Associate Professor of Pediatrics, Genetics and Developmental Biology

Director, Fellowship Program in Pediatric Hematology and Oncology

Director, Pediatric Cancer Predisposition Program

Washington University in St. Louis

Department of Pediatrics

Division of Hematology and Oncology

Center for Genome Sciences and Systems Biology

St. Louis, MO 

USA