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In recent years, there has been an increasing awareness of the genotoxic potential of a wide variety of synthetic hormones that widely used in medicine largely for their potent anti-inflammatory and immunosuppressive activities. Hydrocortisone, synthetic preparation of steroid hormone cortisol, is chosen for the present study for several reasons:1) it is widely used for treatment of a variety of inflammation, asthma, allergic, cancer and immune diseases; 2) very few data are available concerning the genotoxic hazard of hydrocortisone in mice. Considering this, the present work was carried out...