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Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated with human health and disease. This book presents a unified discussion of the statistical concepts applied in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. The development involves elementary principles of...

Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated with human health and disease. This book presents a unified discussion of the statistical concepts applied in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. The development involves elementary principles of...

In June 2010, a conference, Probability Approximations and Beyond, was held at the National University of Singapore (NUS), in honor of pioneering mathematician Louis Chen. Chen made the first of several seminal contributions to the theory and application of Stein's method. One of his most important contributions has been to turn Stein's concentration inequality idea into an effective tool for providing error bounds for the normal approximation in many settings, and in particular for sums of random variables exhibiting only local dependence. This conference attracted a large audience...