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This issue discusses the diagnosis and treatment of major depressive disorder (MDD) and other depressive disorders, with an emphasis on the psychosocial aspects of depression: how it affects societies, how it is affected by culture, and what the true meaning of recovery is for those suffering from MDD. The issue is divided into three section: Etiology, Diagnosis and Treatment.? Authors address the evidence where biology and subjectivity meet.? They discuss what is adaptive and what is pathologic and discuss population-based solutions that take into account the specificity of the individual.?...