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Advances in cell, developmental and molecular biology, and the discovery of regeneration-competent cells in many non-regenerating mammalian tissues, have given impetus to systematic investigations that will enable us to regenerate these tissues by cell transplantation or the pharmaceutical induction of regeneration from the body's own tissues. A significant avenue of research is the identification of the soluble and insoluble signals and their transduction pathways that govern the proliferation and differentiation of regeneration-competent cells, and the signals that inhibit their activity...

Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essential developmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term "regenerative medicine" was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed...

This is an opinion piece from a highly qualified professor of science who has served in administration highlights the need for reform in our public higher education research institutions. In this well-researched reference, Dr. Stocum illustrates how the competition among the public flagship universities for more money, research prestige, and power, and the imposition of mission differentiation on public universities, is detrimental to the educational needs of 21^st century. The goal of the work is to expose the issues that exist, give a voice to under-recognized institutions and...