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This book contains the refereed contributions from the 42nd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of...

Metastatic Disease of the Nervous System begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system. The largest section of the volume comprehensively reviews all aspects of brain metastases, from clinical, radiological and neuropathological manifestations to the roles of surgery, radiation, systemic and palliative therapy in their management; the complications of these interventions are also discussed. The clinical manifestations, diagnosis, and treatment of leptomeningeal, dural, spinal epidural, and plexus...

Originally formed around a set of lectures presented at a NATO Advanced Study Institute (ASI), this book has grown in scope and in aspiration to become organised and presented rather more as a textbook than as a standard collection of proceedings . The lack of a unified reference textbook covering both the science of seasonal to interannual predictions and real-world uses of the forecasts was the main driver for the effort placed into writing an amalgamated introductory book, each chapter of which has been thoroughly peer reviewed. Throughout, our objective has been to present a book...

Originally formed around a set of lectures presented at a NATO Advanced Study Institute (ASI), this book has grown in scope and in aspiration to become organised and presented rather more as a textbook than as a standard collection of proceedings . The lack of a unified reference textbook covering both the science of seasonal to interannual predictions and real-world uses of the forecasts was the main driver for the effort placed into writing an amalgamated introductory book, each chapter of which has been thoroughly peer reviewed. Throughout, our objective has been to present a book...