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The focus of this book is the modeling of the location of economic activities, measured in terms of employment, in land-use and transportation systems. These measures are key inputs to models at intra-urban scales of the flows of persons and goods for both urban and transport planning. The models described here are either components of comprehensive models or specialist studies. Economic activities can be defined in terms of jobs or private-sector firms and public service organisations. Different levels of aggregation are used both in terms of organisational and geographical dimensions. In...

A secret, military project is in the process of colonising a planet called Springfield. When contact with Earth is lost, the Springfielders are forced to look out for themselves. In this story about alternative worlds, there are alternative endings. In the first, aggressive aliens arrive, forcing the Springfielders to choose between fight and flight. In the second ending, a machine intelligence seems to offer renewed contact with Earth. Unwittingly, it attracts an apparition previously believed to exist only in legend.

Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and...

This book explores the modeling of the location of economic activities, measured in terms of employment, in land-use and transportation systems, as key parts of models depicting the flows of people and goods at intra-urban scale, for use in transport planning.