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Lane-changing studies have attracted increased attention during recent years. However, limited research has been conducted to address the probability of changing lanes and vehicle interactions that occur. The objective of this book is to model urban lane-changing maneuvers by using data related to driver behavior. Two components were developed from field data, for lane-changing probability and for gap acceptance. Experiments were conducted to collect the corresponding lanechanging data: a focus group study and an in-vehicle driving test. The proposed lane-changing model was implemented in the...

Many proprotein convertases (PC), especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases. In this chapter, we review mostly our work using animal models of squamous cancers that have been induced by chemical or UV carcinogenesis protocols to highlight the role of PCs in the development and progression of experimental tumors. After demonstrating in wild-type mice the role of PACE4 in tumor progression, as well as detecting the...