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An efficient catalytic system for the synthesis of quinolinyl ureas have been developed using Pd based catalyst system. All these synthesized quinolinyl ureas have adequate pledge as active drug candidates via a novel process. The in vitro biological screening data of the newly synthesized analogs revealed that majority of the compounds have demonstrated noticeable antimicrobial against various panels of microorganisms.

The book is focusing on novel progress of Pd catalyzed C-N coupling of weak nucleophile: Urea and Amide.Although a number of book dealt with transition metal catalyzed N-arylation of amines (all classes), to date no specific book covering the Palladium catalyzed N-arylation of amide and urea appeared. This book increases the practicality of amidation and ureidation applications through the concise analysis of previous work. This book discusses these developments with regard to substrate scope and the nature of the corresponding catalyst systems. Emphasis will be placed on applications of...