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In the present and subsequent volumes of this book, critical coverage of the literature will be combined with the fruits of original and highly relevant research carried out by Dr. D.M Aviado and his colleagues. The total effort constitutes an authoritative up-to-date appraisal of the knowledge needed to understand the inhalational toxicity and other biological effects of an important and ubiquitous class of chemical agents.

The present volume does not deal with a single chemical but with three solvents and three propellants that are likely to be used in aerosol products. Although it is common practice to combine solvents and propellants in pressurized containers, there has been no previous attempt to examine each constituent singly and in combination.

D.A. KHARKEVICH The history of the study of ganglionic substances begins with the paper of LANGLEY and DICKINSON (1889), who established the ability of nicotine to block the neurones in the superior cervical ganglion. This was a considerable discovery as the authors ascertained that impulses were transmitted from pre- to postganglionic neurones in the autonomic ganglia. Simultaneously they indicated the possibility of pharmaco- logical influence upon interneuronal transmission in autonomic ganglia. The idea of ganglionic receptors specifically sensitive to nicotine followed logically. Later,...

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