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This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

• Explores the current concepts in drug metabolism and toxicology
• Chapters cover such areas...

Graham has come to terms with his special gift. A telepathic connection with children who need help, but his efforts to help them are often accompanied by calamity.

The tiny group who know his secret decide he needs their protection, but just how effective can Nancy, his partner, a GP, a social worker and an overweight detective sergeant be?

They are joined by Harvey Calder, a wealthy business man. He and his wife Audrey are indebted to Graham for saving their granddaughter's life, which prompts them to give Graham, Nancy and their foster child, Jimmy, a holiday of a lifetime. But...

Graham Parsons is a "man ordinaire" whose well-ordered life is changed beyond measure when he witnesses the manslaughter of a 7 year old boy, Christopher. Whilst holding the dying child he experiences a profound out of body experience and minutes later suffers a life threatening attack, leaving him with permanent disabilities.

His recovery brings with it a telepathic connection with children who need help. An affinity which threatens his sanity, marriage and eventually his life.

This tale of discovery begins with a fearful and confused denial which takes him to the edge of reason...

Graham Parsons is back in England, a fugitive from US law, but his freedom is still threatened by a vengeful US Senator and extradition.

His life goes on hold, in a stasis of anxiety while in America, Chrissy Haddon and her mother confront their own demons of abuse and alcoholism. Is it time for Senator Haddon to answer for his deeds and make amends?

The "Gang" rally to Graham's side once more, with support and practical help on both sides of the Atlantic that become quite extraordinary. But like Graham, with his telepathic connection with children needing help, they all know others...