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The present investigation was carried out in the period 1977-1981 at the Department of Soil Science and Plant Nutrition of the Agricultural University Wageningen, Netherlands. This university supplied the major financial sup port through a research grant, with additional financial support rendered by the Dutch Nitrogen Fertilizer Industry and Unilever Research, Netherlands. This support is gratefully acknowledged. In the present form this report is the author's doctoral dissertation submitted to the Faculty of the Agricul tural University. The author hereby wishes to thank prof. dr. ir. A....

The desirability of quality-assay of ingestable or imbibable material has resulted in an established procedure in advanced countries. Testimony to its necessity was borne by the scandal of chateau-bottled Bordeaux crus classes a few years ago, a litigation instigated by the disillusioned consumers who either on the basis of absence of the expected inebriate state, or of the olfacto-gustatory caress by the bouquet or full-bodied lingering pharyngeal sensation, decided to strike a paranoid attitude, which ultimately proved to be justified. When one proceeds from sheer pleasure to dire...

The author of this Foreword has recently retired after spending 25 years in academia and 15 years in the pharmaceutical industry. Most of this time has been spent following and, hopefully in some instances, contributing to advancement of the discipline of pharmacokinetics. During the last 40 years, pharmacokinetics has grown from a fledgling in the 1950s to an adult in the 1990s. The late development of the discipline of pharmacokinetics, relative to other disciplines such as chemistry, bio- chemistry, and pharmacology, probably stems both from general ignorance of the importance of the time...