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The last decade (between 2000 and 2010) was designated as the Bone and Joint Decade by the UN and the WHO to raise public awareness of the ever-growing burden of musculoskeletal and locomotion disorders on society. One of the tissues involved is cartilage-the most unique type of connective tissue in the body. Calcium homeostasis and poly(ADP-ribose) polymerase (PARP) dependent pathways represent two important aspects of in vitro chondrogenesis. Calcium, the most ubiquitous signalling factor, regulates many aspects of cartilage differentiation. As cartilage is an avascular tissue...