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Angiotensin-converting enzyme (ACE) is a well-known zinc-metallopeptidase that converts angiotensin I to the potent vasoconstrictor angiotensin II and degrades bradykinin, a powerful vasodilator, both for the regulation of vascular tone and cardiac functions. Other natural substrates of ACE were identified broadening the functions of this enzyme within different physiological contexts such as neuronal metabolism, hematopoiesis, digestion, and reproduction. In this context, ACE has an essential role in diseases, for instance, hypertension, Alzheimers disease, oxidative stress, sperm maturation...

The Fourth International Conference on Unconventional Computation, UC 2005, organized under the auspices of EATCS by the Centre for Discrete Mathematics and Theoretical Computer Science and the Department of C- puter Science and Arti?cial Intelligence of the University of Seville, was held in Seville, October 3-7, 2005. Seville, one of the most beautiful cities in Spain, is at its best in October. An explosion of colour and contrast: ?amenco, bull?ghting, and a lively at- sphere in the streets due to the open and friendly nature of its people. The river Guadalquivir, the Cathedral and the...