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Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent...

In the first of three sections of this book, an overview of "in vitro" toxicology is provided. The molecular biology of cellular toxicity, receptor-mediated mechanisms, structure-activity relationships, pharmacokinetic modeling, and the use of biosensors in toxicological studies are treated in detail. The second section covers some of the very important aspects that allow the analysis of the mechanisms of toxicity, e.g. intercellular communication and signal processing, the cytoskeleton, apoptosis, and free radical mediated toxicity. The last section presents "in " "vitro" studies on...