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In the last few years the use of medical imaging has increased exponentially in routine clinical practice. This has been reflected in a rapidly increasing use of medical imaging in clinical trials, through all phases. More recently this has culminated in a number of inter-disciplinary meetings with the various stake holders, including the FDA. Changes in the regulatory process has resulted, when it comes to the submission of data to the FDA, in a therapeutic agent where one or more of the trial end-points is the assessment of a radiological end-point. No longer is it sufficient to have the...

This illustrated reference takes readers on a revealing tour of a vital, underappreciated piece of our nation's infrastructure.

Imagine Washington, D.C., without its clean and effi cient Metro. Or New York City without the Lincoln and Holland tunnels. Or Boston without the Big Dig. This nation without its tunnels would be a quagmire of clogged streets, urban gridlock, massive sewage and water pipes along our sidewalks, and train routes that would take hours longer just to veer around a mountain instead of going straight through it. Unlivable.

Tunnels have been built for 200...