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Extrinsic geometric flows are characterized by a submanifold evolving in an ambient space with velocity determined by its extrinsic curvature. The goal of this book is to give an extensive introduction to a few of the most prominent extrinsic flows, namely, the curve shortening flow, the mean curvature flow, the Gauss curvature flow, the inverse-mean curvature flow, and fully nonlinear flows of mean curvature and inverse-mean curvature type. The authors highlight techniques and behaviors that frequently arise in the study of these (and other) flows. To illustrate the broad applicability of...

Extrinsic geometric flows are characterized by a submanifold evolving in an ambient space with velocity determined by its extrinsic curvature. The goal of this book is to give an extensive introduction to a few of the most prominent extrinsic flows, namely, the curve shortening flow, the mean curvature flow, the Gauss curvature flow, the inverse-mean curvature flow, and fully nonlinear flows of mean curvature and inverse-mean curvature type. The authors highlight techniques and behaviors that frequently arise in the study of these (and other) flows. To illustrate the broad applicability of...

This textbook is a comprehensive overview of the emerging field of cell-based biopharmaceuticals starting from the underlying biology of stem cell and cell-based products all the way to the initiation of a pivotal clinical trial and the potential business model behind it.It also takes into consideration the different regulatory landscapes in Europe, North America and other parts of the world and describes a way to manufacture a pharmaceutical-grade therapeutic that passes all necessary quality measures as a robust and marketable product. This is an important guide for any professional in the...