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Extrinsic geometric flows are characterized by a submanifold evolving in an ambient space with velocity determined by its extrinsic curvature. The goal of this book is to give an extensive introduction to a few of the most prominent extrinsic flows, namely, the curve shortening flow, the mean curvature flow, the Gauss curvature flow, the inverse-mean curvature flow, and fully nonlinear flows of mean curvature and inverse-mean curvature type. The authors highlight techniques and behaviors that frequently arise in the study of these (and other) flows. To illustrate the broad applicability of...

This textbook is a comprehensive overview of the emerging field of cell-based biopharmaceuticals starting from the underlying biology of stem cell and cell-based products all the way to the initiation of a pivotal clinical trial and the potential business model behind it.It also takes into consideration the different regulatory landscapes in Europe, North America and other parts of the world and describes a way to manufacture a pharmaceutical-grade therapeutic that passes all necessary quality measures as a robust and marketable product. This is an important guide for any professional in the...