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Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and...

This collection of essential documents bearing on the long-standing Arab-Israeli conflict begins with Leo Pinsker's pamphlet of 1882 which first proposed the establishment of a Jewish state, preferably in Palestine, and ends with the United Nations Security Council resolution of 1990. Issued by the various official and quasi-official governments and organizations that have been parties to the dispute, the documents provide the background to political Zionism and illustrate Great Britain's role in both supporting the establishment of a Jewish homeland in Palestine and in easing Arab fears....