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Exposure Assessment and Safety Considerations for Working with Engineered Nanoparticles
ISBN-13: 9780470467060 / Angielski / Twarda / 2015 / 312 str.
Exposure Assessment and Safety Considerations for Working with Engineered Nanoparticles
ISBN-13: 9780470467060 / Angielski / Twarda / 2015 / 312 str.
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Addresses health and safety issues associated with workplace Nanoparticle exposures
- Describes methods to evaluate and control worker exposures to engineered nanoparticles
- Provides guidance for concerned EHS professionals on acceptable levels of exposure to nanoparticles
- Includes documentation on best practices to be followed by all researchers when working with engineered nanoparticles
- Describes current knowledge on toxicity of nanoparticles
- Includes coverage on Routes of Exposure for Engineered Nanoparticles
While invaluable for their uses in medicine as a drug delivery system or as an imaging agent in cancer detection, nanoparticles do present possible medical and environmental dangers.
Preface xiii
1 Introduction 1
1.1 Why A Book on Nanotechnology Health and Safety? 1
1.2 Some Scenarios 3
1.3 Organization of the Material 5
1.4 Our Approach to Nanoparticle Health and Safety 5
References 7
2 What is a Nanoparticle? 8
2.1 Nanotechnology, Nanomaterials, and Nanoparticles 9
2.1.1 Nanotechnology 9
2.1.2 Nanomaterial 9
2.1.3 Nanoparticle 9
2.2 Naturally Occurring Nanoparticles 10
2.3 Industrial Nanoparticles 12
2.4 Engineered Nanoparticles 14
2.4.1 Carbon Nanotubes 15
2.4.2 Fullerenes 17
2.4.3 Quantum Dots 17
2.5 Emerging Uses for Engineered Nanoparticles 19
2.6 Other Useful Definitions 20
2.6.1 Aerosol 20
2.6.2 Particle Inertia 21
2.6.3 Brownian Motion 22
2.6.4 Particle Diameter 23
2.6.5 Agglomerate versus Aggregate 24
2.7 Summary 25
References 26
3 Why are we Concerned? The Unique Properties of Nanoparticles 28
3.1 Surface ]to ]Volume Ratio 28
3.2 Particle Size 30
3.3 Particle Concentration 32
3.4 Dose Metrics: Particle Number, Surface Area, Morphology, and Surface Properties 33
3.5 Implications for the Occupational and Environmental Health Impacts of Nanoparticles 33
3.5.1 Respiratory Deposition 33
3.5.2 Skin Penetration 34
3.6 Implications for Physical Risks 35
3.6.1 Introduction 35
3.6.2 Current Status 35
3.6.3 Conclusions 36
3.7 Summary 37
References 37
4 Routes of Exposure for Engineered Nanoparticles 39
4.1 Introduction 39
4.2 Engineered Nanoparticle Exposure through Inhalation 40
4.2.1 Human Respiratory System 40
4.2.2 Particle Deposition in the Respiratory System 43
4.3 Engineered Nanoparticle Exposure Through Dermal Contact 46
4.4 Engineered Nanoparticle Exposure Through Ingestion 48
4.5 T ranslocation of Nanoparticles from the Lung 48
4.6 Summary 49
References 49
5 Current Knowledge on the Toxicity of Nanoparticles 51
5.1 Introduction 51
5.2 The Toxicity of Industrial Nanoparticles 52
5.3 Nanoparticle Toxicity: General Concepts 53
5.3.1 Routes of Exposure 53
5.3.2 In Vivo and In Vitro Testing 53
5.4 Carbon Nanotubes 54
5.5 Fullerenes 56
5.6 Quantum Dots 58
5.7 Metal ]Based Nanoparticles 58
5.8 Summary 59
References 60
6 Sources of Exposure 63
6.1 Overview of Occupational Exposures 63
6.2 Occupational Exposures in Research Facilities 64
6.3 Occupational Exposures in Manufacturing Facilities 65
6.4 Exposure Potential for ENPs in Different Physical States 66
6.4.1 Dry Powders 66
6.4.2 Liquid Suspensions 69
6.4.3 ENPs Bound to a Solid 72
6.5 Environmental Exposures to Engineered Nanoparticles 73
6.5.1 Environmental Releases 73
6.5.2 Exposures Through a Product s Life Cycle 74
References 76
7 Evaluation of Exposures to Engineered Nanoparticles 79
7.1 Current Knowledge Concerning Exposure to Engineered
Nanoparticles 79
7.2 Exposure to Engineered Nanoparticles by Inhalation 81
7.2.1 Mass Sampling 81
7.2.2 Surface Area Measurement 83
7.2.3 Number Concentration Measurement 84
7.2.4 Conversion between Number, Surface Area, and Mass Concentrations 98
7.2.5 Particle Characterization 99
7.3 Dermal Exposures to Engineered Nanoparticles 102
7.4 Evaluation of Exposures in Aquatic Environments 104
7.4.1 Introduction 104
7.4.2 Sample Collection 104
7.4.3 Measurement Methods 105
7.4.4 Exposure Characterization in Aquatic Environments 107
References 108
8 Exposure Characterization 112
8.1 Exposure Characterization Steps 113
8.1.1 Standard Occupational Hygiene Models 113
8.1.2 Exposure Characterization for Nanomaterials 113
8.2 Exposure Measurement Strategies 120
8.2.1 Single ]Location Measurement 120
8.2.2 Multiple ]Location Measurement 120
8.2.3 Near ]Field and Far ]Field Measurement 121
8.2.4 Dynamic Personal Sampling Measurement 122
8.3 Data Analysis and Interpretation 123
8.4 Statistical Analysis of Data 124
8.4.1 Pearson Correlation 124
8.4.2 T ]test 125
8.5 Practical Aspects of Aerosol Sampling and Microscopy Techniques 127
8.5.1 Aerosol Sampling Techniques 127
8.5.2 Microscopy Techniques 128
8.6 Practical Applications and Limitations 128
8.6.1 Particle Losses 128
8.6.2 Concentration Measurement versus Particle Samples 130
8.7 Typical Production Processes 130
8.7.1 Synthesis of Carbon Nanotubes 130
8.7.2 Composite Manufacture 131
8.8 Case Study: Manual Handling of Nanoparticles 133
8.8.1 Materials and Conditions 134
8.8.2 Particle Handling 134
8.8.3 Measurements 134
8.8.4 Aerosol Particle Characterization 136
8.8.5 Results 137
8.8.6 Discussion 144
8.8.7 The Challenge and Brainstorming 145
8.8.8 Study Questions 145
8.9 Case Study: Synthesis of Carbon Nanotubes 146
8.9.1 Materials and Synthesis 146
8.9.2 Measurement 147
8.9.3 Results 148
8.9.4 The Challenge and Brainstorming 155
8.9.5 Study Questions 156
8.10 Case Study: Exposure From Twin Screw Extrusion Compounding 156
8.10.1 Materials and Production Process 157
8.10.2 Measurements 158
8.10.3 Results 158
8.10.4 The Challenge and Brainstorming 162
8.10.5 Study Questions 163
References 164
9 Control of Occupational Exposures to Engineered Nanoparticles 166
9.1 Control of Airborne Exposures 166
9.1.1 General 166
9.1.2 Laboratory Fume Hoods 169
9.1.3 Alternatives to Conventional Fume Hoods 178
9.2 Control of Dermal Exposures 181
9.2.1 General 181
9.2.2 Clothing and Personal Protective Equipment 181
9.3 Administrative Controls and Good Work Practices 182
9.3.1 Housekeeping 183
9.3.2 Work Practices 183
9.3.3 Worker Training 183
9.4 Respiratory Protection 185
9.4.1 General Considerations 185
9.4.2 Respirator Designs 186
9.5 Case Study: Comparison of the Performance of Various Fume Hoods 195
9.5.1 Materials and Hoods 195
9.5.2 Measurements 198
9.5.3 Results 198
9.5.4 The Challenge and Brainstorming 206
9.5.5 Study Questions 206
9.6 Case Study: Performance of Nontraditional Fume Hoods 206
9.6.1 Materials and Hoods 207
9.6.2 Measurements 207
9.6.3 Results 207
9.6.4 The Challenge and Brainstorming 214
9.6.5 Study Questions 215
References 215
10 Control of Environmental Exposures 219
10.1 Control of Air Emissions 219
10.1.1 Factors Affecting Air Cleaner Performance 220
10.1.2 Categories of Air Cleaning Devices 220
10.2 Control of Water Emissions 228
10.3 Nanoparticles in Solid Waste 232
10.4 Control of Exposures Throughout a Product s Life Cycle 233
10.5 Uncertainties and Needed Research 234
10.6 Case Study Filtration Control 234
10.6.1 Materials and Process 235
10.6.2 The Challenge and Brainstorming 246
10.6.3 Study Questions 246
References 247
11 The Regulatory Environment for Engineered Nanomaterials 249
11.1 Occupational Health Regulations 250
11.1.1 Occupational Health Regulations in the European Union 250
11.1.2 US Occupational Health Regulations 252
11.1.3 Summary: Occupational Exposure Regulations 256
11.2 Environmental Regulations 257
11.2.1 US Environmental Regulations 257
11.2.2 Environmental Regulations in the European Union 261
11.3 Comparison of Nanotechnology Regulation under TSCA and REACH 263
11.3.1 The Precautionary Principle and the Burden of Proof 263
11.3.2 Differences in Handling New and Existing Chemicals 264
11.3.3 Volume ]Based Thresholds and Exemptions 265
11.4 Private Law 265
11.5 Conclusions 266
References 266
12 Future Directions in Engineered Nanoparticle Health and Safety 269
12.1 Where we are Today 269
12.1.1 Research Efforts in the United States 269
12.1.2 Research Efforts in Europe 273
12.1.3 Progress toward Research Goals 273
12.2 Human Health Effects Studies 276
12.3 Exposure Assessment 276
12.3.1 Future Needs in Exposure Assessment Techniques 276
12.3.2 The Development of Occupational Exposure Limits 278
12.4 Optimal Approaches to Control Exposures 279
12.4.1 Engineering Control of Occupational Exposures 279
12.4.2 Control Banding 280
12.4.3 Respiratory Protection 280
12.4.4 Safe Work Practices 281
12.4.5 Air Pollution Control of Nanoparticles 281
12.4.6 Water Pollution Control of Nanoparticles 281
12.4.7 Nanoparticles in Waste Streams 282
12.5 The Future of Regulation 282
12.6 Conclusions 282
References 283
Index 285
Michael Ellenbecker, Emeritus Professor of Occupational and Environmental Hygiene and Director of the Toxics Use Reduction Institute at the University of Massachusetts Lowell, has published widely on the measurement and control of airborne contaminants. He is co–author of the Wiley textbook Ventilation for Control of the Work Environment, 2d edition. For the past ten years he has led the nanoparticle health and safety efforts at UMass Lowell.
Candace Tsai, Assistant Professor of Occupational Health and Industrial Hygiene at Purdue University, and previously Manager for EHS research at UMass Lowell, has led groundbreaking research in exposure assessment and engineering controls associated with nanotechnology development. She received her doctorate in occupational and environmental hygiene and cleaner production at UMass Lowell. Dr. Tsai also has Master s degrees in chemical engineering and management science of business administration. Dr. Tsai has evaluated the potential for nanoparticle exposure in laboratories at many universities and private companies, and developed control techniques and strategies to eliminate exposure in more than a dozen of them.
Addresses acceptable Nanoparticles levels of exposures and identifies best practices to follow to control such exposures
Exposure Assessment and Safety Considerations for Working with Engineered Nanoparticles addresses what is currently known about acceptable levels of exposures to nanoparticles are and identifies best practices to follow to evaluate and control such exposures. The field of nanotechnology health and safety is growing rapidly, due to the thousands of commercial and medical applications for engineered nanoparticles that are currently available or under development, and there is a strong need for knowledge and guidelines associated with the evaluation and control of engineered nanoparticle exposures.
Exposure Assessment and Safety Considerations for Working with Engineered Nanoparticles features:
Methods to evaluate and control worker and environmental exposures to engineered nanoparticles
Guidance for concerned EHS professionals on acceptable levels of exposure to nanoparticles
Best practices to be followed by all researchers when working with engineered nanoparticles
Knowledge on toxicity of nanoparticles
The book includes a wide range of topics, including why we should be concerned about nanoparticle exposure, the current knowledge on the toxicity of nanoparticles, and evaluation and control of exposure. The authors illustrate evaluation and control methods through the use of detailed case studies drawn from their research.
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