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Recent research on the syntax of signed languages has revealed that, apart from some modality-specific differences, signed languages are organized according to the same underlying principles as spoken languages. This book addresses the organization and distribution of functional categories in American Sign Language (ASL), focusing on tense, agreement, and wh-constructions.Signed languages provide illuminating evidence about functional projections of a kind unavailable in the study of spoken languages. Along with manual signing, crucial information is expressed by specific movements of the...

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies.

Therapeutic Applications of Quadruplex Nucleic Acids provides a single...

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still...