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The clinical applications of human gene therapy have been particularly fruitful in oncology, and in the past two decades there has been explosive growth in understanding of the genetic lesions leading to neoplasia. This volume in the series Cancer: Clinical Science in Practice reviews progress in the basic and clinical science of gene therapy in oncology, and looks toward future developments. It considers what has worked and what has not in the fast-evolving field of gene therapy, drawing on laboratory studies and clinical trials, including the ground-breaking work of the contributors...

The clinical applications of human gene therapy have been particularly fruitful in oncology, and in the past two decades there has been explosive growth in understanding of the genetic lesions leading to neoplasia. This volume in the series Cancer: Clinical Science in Practice reviews progress in the basic and clinical science of gene therapy in oncology, and looks toward future developments. It considers what has worked and what has not in the fast-evolving field of gene therapy, drawing on laboratory studies and clinical trials, including the ground-breaking work of the contributors...

The study of greenhouse climates in the earth's past leads to a greater understanding of the factors that influence today's climate. In this fully integrated volume, leading experts in paleoclimatology present cutting edge paleontological, geological, and theoretical research to assess intervals of global warmth. Coverage examines warm climate intervals during the Paleozoic, Mesozoic and Cenozoic from the same perspectives: oceanic and terrestrial, theoretical and observational. This approach illuminates the differences and, more importantly, the commonalities of warm climate intervals. The...