Wyniki wyszukiwania:

Oral drug delivery is the most desirable and preferred method of administering therapeutic agents for their systemic effects. In addition, the oral medication is generally considered as the first avenue investigated in the discovery and development of new drug entities and pharmaceutical formulations, mainly because of patient acceptance, convenience in administration, and cost-effective manufacturing process. For many drug substances, conventional immediate-release formulations provide clinically effective therapy while maintaining the required balance of pharmacokinetic and pharmacodynamic...

Many compounds of this group have an acute and moderate chronic toxicity that manifests itself with the frequent introduction of toxic and sublethal doses. The high activity of phosphatases, carboxyesterases and amidases in the organ-isms of warm blooded animals result in the rapid decomposition of organo-phosphorous compounds into non toxic water soluble products which is ex-creted through urine. The dermal toxicity of organophosphorous insecticide is not high but toxicants like methyl-parathion are highly toxic when they get into the skin. Several methods have been used for the...