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Few experts in the world know more about Asian epidemics than Dr. Luke Lucas and his microbiologist wife, Lynn. But as a stream of new patients travel from the same city in Uzbekistan to the emergency room at University Hospital in San Francisco, each hopes for a miracle that the doctors are not sure they can deliver.

As the hospital's capacity is tested with patients battling tuberculosis caused by microbes resistant to all antibiotics, other victims wander the city, coughing amid crowds of people and creating a public health disaster. Now forced to battle against the complacency of...

It is 1979, and a young man lying on the ground shivering from septic shock is taken to an emergency room, where doctors discover a rare microbe previously assumed harmless. In the ensuing months, the same disease reappears in other victims, all from the Mission District of San Francisco. The epidemic explodes out of control, taking the lives of countless young men, and overwhelming University Hospital microbiologist Lynn Lucas and her colleagues.

Fear grips the city and accusations replace reason, while Lynn and other scientists attempt to determine the source of the lethal outbreak....