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For the clinical diagnosis of myocardial perfusion images there is a need to register 3D datasets originating from different modalities. CT datasets provide good resolution of anatomic structures and are needed for attenuation and scatter correction during the process of SPECT image reconstruction. It is mandatory for this process to have CT and SPECT 3D volumes realigned properly so that reconstruction algorithms can provide physicians with valuable data. Several rigid registration techniques are implemented in commercial solutions for hospitals. These techniques cannot take into account any...