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Lamotrigine comes under the category of anti-epileptic drug. It is a BCS class II drug which is insoluble in water and its half-life is 24-25 hours with 90% bioavailability. To obtain an enhanced in-vitro dissolution rate of Lamotrigine by using Liquisolid technique and Liquisolid tablets were optimized by QbD-DoE approach 32 full factorial design using Design Expert Software. All prepared liquisolid batches were subjected to weight variation, drug content uniformity, hardness, friability test, and disintegration test and dissolution tests. Liquisolid systems were also tested for DSC, FT-IR....