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The aim of present research work was to investigate a microparticles base hydrogel of Atenolol and Propranolol drugs. This study was designed to evaluated the effects of different formulations variables like drug: polymer ratio, drug: Poly Vinyl alcohol (PVA) ratio on various parameters like IQCS & Kurtosis Analysis which includes arithmetic mean diameter, surface length of mean diameter, volume surface mean diameter, weight moment mean diameter, surface number mean diameter, angle of repose, tap density, bulk density, swelling index, In vitro drug release studies, FTIR analysis, differential...

Metoprolol tartrate, a nonselective beta adrenergic blocking agent, is widely used in the treatment of hypertension, angina pectoris and many other cardiovascular disorders. The bioavailability of Metoprolol tartrate is low. Metoprolol tartrate is highly water soluble drug with relatively short biological half-life of 4-5 hrs and usual dose is 25 mg thrice daily. This demands high frequency of administration resulting in oscillation of plasma drug concentration, it is necessary to develop sustained release dosage form with extended clinical effect.Metoprolol Tartrate was formulated as...

Hypertension is one of the primary risk factors for heart disease and stroke, the leading causes of death worldwide. Telmisartan is BCS class II, anti-hypertensive drug.The aim of present work was to develop a Telmisartan nanosuspension for faster onset of action which is essential in hypertension condition. In the present work nanosuspension is prepared by media milling method. Zirconium oxide beads are used as milling media. The optimization was done using 3level3 factor full factorial design.The optimized batch shown particle size is 356 nm,Zeta potential -8.3 and % drug release after...