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Thalassemia is discussed comprehensively by the authors in this issue.? Topics discussed include the population genetics and dynamimcs of thalassemia, alpha thalassemia, HbE/beta thalassemia, management of iron overload in thalassemia syndromes, allogeneic cellular gene therapy for hemoglobinopathies, cord blood transplantation for beta thalassemia major, and gene therapy for hemoglobin disorders.

This volume presents stem cells and gene therapy together in one volume. Advances in molecular genetics and recombinant DNA technology have led to the identification of a plethora of disease causing genes. Encouraged by an understanding of the molecular basis of human disease and its connection to genetic changes that result in abnormal structure and function, human gene therapy research for medical therapeutic purposes has emerged as a global drug development effort.