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Gene therapy is a novel concept of treating diseases at the molec ular level by rescuing genetic defects through the introduction of corrective genes. The knowledge of genetic defects underlying var ious diseases is being rapidly accumulated, and new genotypic findings are being reported with striking frequency. The elucida tion of the genetic background of many diseases, including hered itary blistering and hyperkeratotic skin disorders, has provided the necessary knowledge to correct inborn genetic aberrations in ani mal models and patient-derived tissue. However, skin is not only a target...

This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health.