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Research in the laboratory of Baruch S. Blumberg resulted in the discovery of the hepatitis B virus and the invention of the vaccine which protects against it. This work comprises an account of research on HBV (and related subjects) and selected reprints from Blumberg and his colleagues.

About 375 million people are infected with the hepatitis B virus. It has killed more people than AIDS and also causes millions of cases of liver cancer. The discovery of this deadly virus and the vaccine against it--a vaccine that is sharply decreasing the infection rate worldwide and is probably the first effective cancer vaccine--was one of the great triumphs of twentieth-century medicine. And it almost didn't happen.

With wit and insight, this scientific memoir and story of discovery describes how Baruch Blumberg and a team of researchers found a virus they were not looking...