Acetaminophen Toxicity: Experimental and Clinical Advances

ISBN-13: 9780443158773 / Angielski

Barry Rumack; Hartmut Jaeschke; Mitchell McGill

Spis treści

Part 1: Foundational Aspects 1. History of Acetaminophen 2. Intracellular Signaling Mechanisms of Cell Death. 3. Mode of Cell Death 4. Inflammation 5. Regeneration 6. Biomarkers 7. Emerging Mechanisms 8. Renal Toxicity 9. Pulmonary Toxicity 10. Genomics, Proteomics and Metabolomics Part II: Clinical and Therapeutic 11. N-Acetylcysteine (NAC) 12. Adducts 13. Pre-Hospital and Poison Center Care of Overdose and Potential Overdoses Patients 14. Acetaminophen and Co-Ingestions 15. Current Standard of Care and New Developments 16. Pharmacokinetics 17. Risk Analysis and Acetylcysteine Treatment Protocols 18. Fomepizole 19. Epidemiology NPDS (Poison Center Data) CDC and Other Databases 20. Emerging Treatments 21. Liver Transplantation