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In search of new, effective and safe drugs for the treatment of the immunological system, the progress of research has been so remarkable and significant, that there now lays before mankind a wealth of new starting points and opportunities still to be unexplor and discover. But there remains a considerable gap in the range of drugs available to treat the diseases of the immunological system. Pain is not only associated with physical suffering or hurting but has an emotional or mental component hence its definition by the international association for the studies of pain2 as "an unpleasant...

Inflammation is a host defensive but exaggerates local tissue mechanism in response to various infections, injury or destruction of tissues or any metabolic stimulus. It is a complex phenomenon comprising biochemical as well as immunological factors. The manifestation of acute inflammation is recognized by the symptoms such as redness, swelling and pain. The inflammatory response begins with a release of inflammatory chemicals into the extra cellular fluid, the most important sources of these inflammatory mediators are histamine, prostaglandins and cytokines are products of injured tissue...