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The Mongolian gerbil brain lies in the anatomy of the blood vessels supplying blood to the brain. In all mammals, there is a special mechanism that compensates for the decreased blood flow to the brain in the case of development of stroke. This mechanism is missing in the gerbil and therefore makes the Mongolian gerbil a unique model for stroke. Dr. Mayevsky adopted the gerbil as a model for stroke and his laboratory uniquely studied the mitochondria in the gerbil brain under various pathophysiological conditions.

This book describes the history of the Mongolian gerbil in...

This book covers both the technological development and biomedical applications of NADH fluorescence. Topics covered include perspectives on the history of monitoring NADH fluorescence, the relationship between mitochondrial function and other functions at the tissue level, responses of NADH to physiological and pathophysiological conditions, monitoring of NADH in the human brain and other organs, and metabolism. It also includes an in-depth look at flavoprotein (Fp) fluorescence and NADH in relation to redox state. This is an ideal book for biomedical engineers, researchers, and graduate...

This book covers both the technological development and biomedical applications of NADH fluorescence. Topics covered include perspectives on the history of monitoring NADH fluorescence, the relationship between mitochondrial function and other functions at the tissue level, responses of NADH to physiological and pathophysiological conditions, monitoring of NADH in the human brain and other organs, and metabolism. It also includes an in-depth look at flavoprotein (Fp) fluorescence and NADH in relation to redox state. This is an ideal book for biomedical engineers, researchers, and graduate...

Exposure of patients to a high oxygen environment is a standard treatment in a select group of patients. The development of oxygen toxicity must be avoided in those patients. This book describes the effects of normobaric and hyperbaric oxygen treatment of animal models on brain biochemical and physiological responses. This book provides a summary of our knowledge on the effects of hyperbaric oxygenation on mitochondrial activity in vivo, and other functions of the brain. A chapter covering the use of hyperbaric hyperoxia in patients’ brain pathology and care is also included. This is an...

This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists...