The Human Mitochondrial Genome: From Basic Biology to Disease

ISBN-13: 9780128196564 / Angielski / Miękka / 2020 / 448 str.

Giuseppe Gasparre; Anna Maria Porcelli

Spis treści

Part 1 - Biology of human mtDNA 1. MtDNA replication, maintenance and nucleoid organization 2. Human mitochondrial transcription and translation 3. Epigenetic features of mitochondrial DNA 4. Heredity and Segregation of mtDNA

Part 2 - MtDNA evolution and exploitation 5. Haplogroups and the history of human evolution through mtDNA 6. Human Nuclear mitochondrial Sequences (NumtS) 7. MtDNA exploitation in forensics

Part 3 - MtDNA mutations 8. Human mitochondrial DNA repair 9. Mechanisms of onset and accumulation of mtDNA mutations 10. Mitochondrial DNA mutations and ageing 11. Methods for the identification of mitochondrial DNA variants 12. Bioinformatics resources, databases, and tools for human mtDNA 13. Methods and models for functional studies on mtDNA mutations

Part 4 - MtDNA-determined diseases 14. Mitochondrial DNA point mutation diseases 15. Nuclear genetic disorders of mitochondrial DNA gene expression 16. mtDNA maintenance: disease and therapy 17. MtDNA mutations in cancer 18. MitoTALENs for mtDNA editing 19. Mitochondrially-Targeted Zinc Finger Nucleases 20. Mitochondrial movement between mammalian cells: an emerging physiological phenomenon