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This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to...

In today s society the issue of security has become a crucial one. The use of knowledge-based technology in security applications emerges with important applications in monitoring, control, crisis, and rescue management. This volume contains extended and improved versions of selected contributions presented at the International Workshop "Monitoring, Security and Rescue Techniques in Multiagent Systems" (MSRAS 2004) held in Plock, Poland, June 7-9, 2004, bringing together the world s leading researchers in the field.