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This book tackles the question of why the brain is so difficult to fully understand. In neuroscience, data are acquired and analyzed with astonishing techniques and accumulate rapidly. Nevertheless, try to explain how a person can think or why there is such a condition as schizophrenia, and it appears that we really know little. To approach these difficulties, the authors first present a number of case studies in which the operation of a neural circuit is worked out in some detail and, at the same time, the functional significance of the operation is also understood. These examples are...

Die Patch-Clamp-Technik ist heute eine der wichtigsten neurophysiologischen Arbeitsmethoden. Ihre Anwendung hat in der biomedizinischen Grundlagenforschung bedeutende Erkenntnisse über die Funktion und die Eigenschaften von Ionenkanälen erbracht, und auch aus der angewandten pharmakologischen Forschung ist sie in­zwischen nicht mehr wegzudenken. Klar und praxisbezogen vermitteln die Autoren die wesentlichen Informationen, um die Methode im Labor einzuführen und erfolgreich anzuwenden. Das Buch erläutert die theoretischen Grundlagen der Messung, den detaillierten Aufbau eines Messplatzes...

The patch clamp technique is one of the most important electrophysiological methods in use today. Its application in basic biomedical research has provided significant insights into the function and properties of ion channels, making it equally indispensable in applied pharmacological research. This book is the English edition of the popular German introduction to the patch clamp technique. This introductory book serves as a practical guide for teachers and students, offering clear and practical instructions on patch clamp recordings. The authors provide essential information to establish...