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Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in the tumor microenvironment. The balance between immune cells that support tumor progression and immune cells that sustain tumor-controlling immune surveillance is tightly regulated by various factors originated from both the malignant and non-cancerous cells in the tumor microenvironment. Analysis...