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The human adaptive immune system serves as the primary defense against pathogens. While the human adaptive immune response is powered by many components, the Major Histocompatibility Class II (MHCII) molecules lie at the heart of the machinery of the immune system. MHCII display of antigens triggers a cascade of events leading to the immune response. Lack of MHCII expression causes severe immunodeficiency disorders, whereas overproduction of these molecules can cause a variety of autoimmune diseases. The production of MHCII molecules is regulated by a multi-protein complex that includes the...

A father and daughter's afternoon of cleaning becomes a celebration of the music, food, and culture of New Orleans. It's a quiet Sunday afternoon of chores at Clara's house. Until Clara's dad starts singing and dancing, that is! With a broom and an off-key voice, Dad brings Louisiana jazz to the drudgery of housecleaning. Together, they find music in every household object as they sing and dance through a combination of jazz, blues, soul, and African beats. The entire house transforms into a New Orleans parade, in a day filled with harmony, soul food, family heritage, and joyful memories. ...