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4-Thiazolidinones are one of the emerging classes of heterocyclic privileged scaffold. Because of their biological importance, several methods have been developed for the synthesis of 4-thiazolidinone skeleton. The only method reported for solid phase synthesis of 4-thiazolidinones is by C. P. Holmes. A careful survey of the literature revealed that solid-phase synthesis of 4-thiazolidinone with a suitable methodology has not been reported yet. The challenge is to develop a solid phase methodology that affords fast and easy generation of combinatorial library of 4-thiazolidinones, with high...