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HCV, a major cause of liver disease worldwide, is frequently resistant to the antiviral interferon- therapy, being the only approved treatment available. It has been investigated recently that interleukin-8 (IL-8) induced by HCV partially inhibit the IFN- therapy. Therefore we aimed to prospectively utilize the baseline IL-8 levels in the HCV infected serum and predict its role in sustained virological response (SVR) to IFN- + ribavirin therapy, in chronic HCV patients. Fifteen normal volunteers and 110 HCV patients were enrolled in this study. Their baseline IL-8 levels were determined by...

Pear belongs to genus Pyrus, abundantly found in temperate region of AJ & K reflects rich biodiversity. Such diversity and valuable genetic resources are being eroded due to human over exploitation, and natural calamities. Keeping in view existing genetic diversity and genetic erosion in Pyrus germplasm, the focus of present study was to develop biotechnological conservation strategies by using slow-growth techniques. However in vivo preservation was also implemented to conserve the basic stock under field conditions. The apical shoots of nine pear genotypes were preserved in vitro under...

Geographically, the state of Azad Jammu & Kashmir, is situated in the mountainous region of Northern Pakistan and in the foothills of Himalayas. This region reflects rich biodiversity in Pyrus. Pear stands 2nd in ranking after and is excellent source of carbohydrates, vitamins, mineral and dietary fiber. It is relished for their buttery, juicy, fine texture and flavor and helpful in reducing body weight. Systematic studies for the selection of desirable pear genotypes and fruit quality have not yet been conducted so far. In present studies, promising genotypes were screened out for fruit...