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Penicillin resistance of the bacteria that cause meningitis and pneumonia is a growing global health problem. The incidence of resistance of these organisms to penicillin and some antimicrobial agents has been increasing worldwide. Diseases such as tuberculosis, hepatitis, gonorrhea, malaria, stomach ulcer, and childhood ear infection are now more difficult to treat than they were just a few decades ago. The success of antimicrobial agents against disease-causing microbes is among modern medicine's great achievements. Inspired by previously reported superior resistance activity of...

The theory and principles of gene delivery for therapeutic function have been well documented. Even though viral vectors, weighed against non-viral vectors such as lipoplexes and polyplexes, are far more competent in bringing about cellular transfection, inherent immunity problem compromise their protective use in vivo. Although vulnerabilities consist of mutational insertion hazard and exposure, potentially leading to oncogenicity, large scale production of viral vectors as such might also represent an impediment. Though less efficient, particularly in vivo, both lipoplexes consisting of a...

The theory and principles of gene delivery for therapeutic function have been well documented. Even though viral vectors, weighed against non-viral vectors such as lipoplexes and polyplexes, are far more competent in bringing about cellular transfection, inherent immunity problem compromise their protective use in vivo. Although vulnerabilities consist of mutational insertion hazard and exposure, potentially leading to oncogenicity, large scale production of viral vectors as such might also represent an impediment. Though less efficient, particularly in vivo, both lipoplexes consisting of a...

The protein encoded by the ras genes occupies a central position in the signaling pathways used by cells to respond to growth factors. What apparently happens in cancerous tumors is that as a result of mutations in genes, ras proteins are constantly "turned on" so that they constantly promote cell division, even in the absence of stimulation by growth factors. But before either the normal or mutated ras proteins can do anything they have to undergo a series of modifications that enable them to settle in their final home, a spot on the cell membrane from which they relay growth signals to the...