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Aaron and Stella Alterra had been married for more than sixty years when Aaron began to notice puzzling lapses in his wife's memory. Innocuous at first, they became more severe and more alarming. After a series of appointments and tests, the Alterras were informed that Stella was one of the more than 4.5 million Americans with Alzheimer's disease.

Combining medical research on the disease and often-painful anecdotes of memory loss, deteriorating motor functions, personality shifts, support-group and daycare experiences, and drug trials, Alterra chronicles his transformation from...