Functional Genomics

ISBN-13: 9789401039031 / Angielski / Miękka / 2012 / 200 str.

Chris Town

Opis

This volume provides an overview of the current state of plant genomics using a number of different approaches at a time when we celebrate the completion of the Arabidopsis genome sequence and begin the transition from structural to functional studies of this and other plant genomes. Topics covered include comparative genomics, computational approaches to gene identification and annotation and data management, high throughput methodologies for functional analysis at the levels of transcript, protein and metabolite, and methods for genome modification by both homologous and site-specific recombination. The book will provide a good introduction to some of the many aspects of genomics both for established plant biologists who wish to understand this rapidly developing area and for scientists early in their careers. It is also very suitable for a one-semester course in Plant Genomics at the upper-level undergraduate/graduate student level, where the individual chapters provide a framework that can be readily expanded by use of some of the many articles in the bibliographies.

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Spis treści

Preface. Acknowledgement. Through a genome, darkly: comparative analysis of plant chromosomal DNA; G.J. King. Plant genome evolution: lessons from comparative genomics at the DNA level; R. Schmidt. Computational gene finding in plants; M. Pertea, S.L. Salzberg. Computational modeling of gene structure in Arabidopsis thaliana; V. Brendel, W. Zhu. Surviving in a sea of data: survey of plant genome data resources and issues in building data management systems; L. Reiser, et al. Comprehensive gene expression analysis by transcript profiling; J. Donson, et al. DNA microarrays for functional plant genomics; A. Aharoni, O. Vorst. Microarray data quality analysis: lessons from the AFGC project; D. Finkelstein, et al. Large-scale plant proteomics; B. Kersten, et al. Proteomics and a future generation of plant molecular biologists; J.K.M. Roberts. Metabolomics - the link between genotypes and phenotypes; O. Fiehn. Gene replacement by homologous recombination in plants; H. Puchta. Recombinase-directed plant transformation for the post-genomic era; D.W. Ow.