Epigenetics, Environment, and Genes

ISBN-13: 9781926895253 / Angielski / Twarda / 2013 / 334 str.

Sun Woo Kang

Opis

Epigenetics refers to DNA and chromatin modifications that play an important role in the regulation of various genomic functions. This important book reviews human and cellular data that underline paradoxical findings with respect to the contribution of heredity and environment to phenotype. The contributors then reinterpret these experiments that incorporate epigenetic factors. Topics include DNA methylation, histone modifications, chromatin modifications, the role of epigenetic modifications and environment on gene expression, and integrating genomic medicine into clinical practice.

Spis treści

Preface
From Gene to Epigenomes: Correlating CpG Islands, Motifs, and Sequence Variants: Correlating Cpg Islands, Motifs, and Sequence Variants in Human Chromosome
DNA Methylation: Promoter Hypermethylation: Regulation of the Stem Cell Marker Cd133 Is Independent of Promoter Hypermethylation in Human Epithelial Differentiation and Cancer. Genome-Wide Mapping: Genome-Wide Mapping of Imprinted Differentially Methylated Regions by Dna Methylation Profiling of Human Placentas From Triploidies.
Histone Modifications: Histone (H1) Phosphorylation: Histone H1 Interphase Phosphorylation Becomes Largely Established in G1 or Early S Phase and Differs in G1 Between T-Lymphoblastoid Cells and Normal T Cells. Post-Translational Modifications: Quantitative Analysis of Histone Exchange For Transcriptionally Active Chromatin.
Chromatin Modifications: Generation of Bivalent Chromatin Domains During Cell Fate Decisions.
The Role of Epigenetic Modifications and Environment on Gene Expression: Renal Kallikrein Excretion: Renal Kallikrein Excretion and Epigenetics in Human Acute Kidney Injury: Expression, Mechanisms and Consequences
Cox-2 Gene Expression: Cox-2 Gene Expression in Colon Cancer Tissue Related to Regulating Factors and Promoter Methylation Status. A Combination of Transcriptome and Methylation Analyses: A Combination of Transcriptome and Methylation Analyses Reveals Embryologically Relevant Candidate Genes in Mrkh Patients.
Integrating Genomic Medicine Into the Clinical Practice: Genome Wide Association Study: Genome Wide Association Study to Predict Severe Asthma Exacerbations in Children Using Random Forests Classifiers. Epigenomics of Human Embryonic Stem Cells: Epigenomics of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: Insights Into Pluripotency and Implications For Disease. Inhibitor of Aromatase Promoter: Potential Utility of Natural Products as Regulators of Breast Cancer-Associated Aromatase Promoters.

O autorze

Sun Woo Kang, MD, PhD, is Assistant Professor in the Division of Nephrology of the Department of Internal Medicine a the College of Medicine at Inje University, Korea. Dr. Kang earned his PhD and MD degrees at the Kyung Hee University Medical School in Seoul, Korea. He received a National Kidney Foundation Fellowship at the University of California at San Diego (Division of Nephrology, Department of Medicine) in 2009–2010. He has received several research grants and has several years of clinical trial experience. He is also a published author and presenter at professional meetings.