Voltage Gated Sodium Channels

ISBN-13: 9783662512029 / Angielski / Miękka / 2016 / 295 str.

Peter Ruben

Opis

This volume of Springer's Handbook of Experimental Pharmacology explores the wide range of factors relating to sodium channels, from their biophysical behavior, structure, and pathological vulnerabilities to the methodologies employed in studying them.

Spis treści

Overview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels.- Slow inactivation of Na⁺ channels.- Regulation/modulation of sensory neuron sodium channels.- Ubiquitylation of voltage-gated sodium channels.- Probing gating mechanisms of sodium channel using pore blockers.- Animal toxins influence voltage-gated sodium channel function.- Voltage-sensor trapping toxins: Iso form-specific ligands for sodium channels.- Pharmacological insights and quirks of bacterial sodium channels.- The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.- The role of late INa in development of cardiac arrhythmias.- Proton modulation of cardiac INa: A potential arrhythmogenic trigger.- Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents.