Vitamin-Binding Proteins: Functional Consequences

ISBN-13: 9780367379711 / Angielski / Miękka / 2019 / 300 str.

Krishnamurti Dakshinamurti; Shyamala Dakshinamurti

Opis

Minor changes in the chemical structure of vitamins can cause major differences in their binding to proteins and therefore in their biological activity at the cell, tissue, and organ levels. Illuminating newer areas of vitamin function, this book explores the interface of physiological vitamin function and pharmacological vitamin action. It summarizes the current knowledge base with regard to vitamin-binding proteins, addressing the effects that lead to both normal physiological activity and pharmacological effects with significant therapeutic potential in a wide spectrum of disease processes.

Spis treści

Retinoic Acid: Metabolism, Developmental Functions, and Evolution. Serum Retinol-Binding Protein, Obesity, and Insulin Resistance. Retinoic Acid and Immunity. Vitamin D3 Up-Regulated Protein 1 (VDUP1) and the Immune System. Rapid Pre-Genomic Responses of Vitamin D. The Role of Vitamin D in Infectious Processes. Vitamin D, Vitamin D Binding Protein, and Cardiovascular Disease. Vitamins E and C: Effects on Matrix Components in the Vascular System. Vitamin K and Vascular Calcification. Therapeutic Effects of Pyridoxamine and Benfotiamine. Multifaceted Therapeutic Potential of Vitamin B6. Non-Prosthetic Group Functions of Biotin. Mechanisms of Gene Transcriptional Regulation Through Biotin and Biotin-Binding Proteins in Mammals. Folate Receptor-Mediated Therapeutics: Folate Receptor- Mediated Particle Systems for Drug and Gene Delivery in Cancer Therapy. Vitamin B12 Derivatives and Preferential Targeting of Tumors. Ascorbic Acid, Binding Proteins, and Pathophysiology.

O autorze

Krishnamurti Dakshinamurti is an emeritus professor of biochemistry and molecular biology at the University of Manitoba, Winnipeg, Canada. He is the author of more than two hundred peer-reviewed publications and four books in the areas of metabolic biochemistry and neuroscience. The monograph on "Vitamin Receptors," which he edited in 1994, was reprinted by Cambridge University Press in 2010 in their classics series. Dr. Dakshinamurti was elected to emeritus professorship of the University of Manitoba in 1998. He was codirector of the Centre for Health Policy Studies at the St. Boniface Hospital Research Centre. Currently he is the senior advisor of the Research Centre.

Shyamala Dakshinamurti is a neonatologist and biomedical researcher at the University of Manitoba. She was appointed to the Department of Physiology in 2005 and became associate professor of pediatrics in 2008. Since 2005, she has been the coordinator of neonatal research for the eclectically disparate research streams within the section of neonatology. She organizes the annual international Bowman Symposium in Neonatal Research and is the research director for the U of M Neonatology Fellowship Program. Dr. Dakshinamurti was appointed Dr. F.W. Du Val Clinical Research Professor in the Faculty of Medicine. Her research interests are pulmonary hemodynamics during circulatory transition and the physiology and pharmacology of vascular smooth muscle.