Vaccine Design: Methods and Protocols, Vol. 3. Resources for Vaccine Development

ISBN-13: 9781071618912 / Angielski / Twarda / 2021

Sunil Thomas

Spis treści

PART I TRENDS IN VACCINE DEVELOPMENT

1. Artificial Intelligence for Vaccine Design

Peter McCaffrey

 

2. Progress in the Development of Structure-Based Vaccines

Sunil Thomas and Ann Abraham

 

3. Polymer-Peptide Conjugate Vaccine for Oral Immunization

Mohammad Omer Faruck, Mariusz Skwarczynski, and Istvan Toth

 

4. An update on “Reverse Vaccinology”: The Pathway from Genomes and Epitope Predictions to Tailored, Recombinant Vaccines

Marcin Michalik, Bardya Djahanshiri, Jack C. Leo, and Dirk Linke

 

PART II VACCINE VECTORS AND PRODUCTION SYSTEM

5. Phage T7 as a Potential Platform for Vaccine Development

Chuan Loo Wong, Chean Yeah Yong and Khai Wooi Lee

 

6. Plant-based Systems for Vaccine Production

Mattia Santoni, Elisa Gecchele, Roberta Zampieri, and Linda Avesani

 

7. Production of a Hepatitis E Vaccine Candidate Using the Pichia pastoris Expression System

Jyoti Gupta, Amit Kumar, and Milan Surjit

 

PART III VACCINE ADJUVANTS

8. Developments in Vaccine Adjuvants

Farrhana Ziana Firdaus, Mariusz Skwarczynski, and Istvan Toth

 

9. Adjuvants: Engineering Protective Immune Responses in Human and Veterinary Vaccines

Bassel Akache, Felicity C. Stark, Gerard Agbayani, Tyler M. Renner and Michael J. McCluskie

 

10. Cationic Nanostructures as Adjuvants for Vaccines                                                                                                     

Ana Maria Carmona-Ribeiro, Beatriz Ideriha Mathiazzi, and Yunys Pérez-Betancourt

 

11. Emulsion Adjuvants for Use in Veterinary Vaccines

Rachel Madera, Yulia Burakova, and Jishu Shi

 

12. Generation of a Liposomal Vaccine Adjuvant Based on Sulfated S-lactosylarchaeol (SLA) Glycolipids

Bassel Akache, Yimei Jia, Vandana Chandan, Lise Deschatelets and Michael J. McCluskie

 

13. Glucan particles: choosing the appropriate size to use as a vaccine adjuvant

Mariana Colaço, João Panão Costa, and Olga Borges

 

PART IV VACCINE DELIVERY SYSTEMS      

14. Use of Optical In Vivo Imaging to Monitor and Optimize Delivery of Novel Plasmid-Launched Live-Attenuated Vaccines

Sapna Sharma and Kai Dallmeier

 

15. Liposomes for the Delivery of Lipopeptide Vaccines

Jieru Yang, Armira Azuar, Istvan Toth, and Mariusz Skwarczynski

 

16. Current Prospects in Peptide-Based Subunit Nanovaccines

Prashamsa Koirala, Sahra Bashiri, Istvan Toth, and Mariusz Skwarczynski

 

17. Design and Synthesis of Protein-based Nanocapsule Vaccines

Ivana Skakic, Jasmine. E. Francis, and Peter. M. Smooker

 

18. Design and Preparation of Solid Lipid Nanoparticle (SLN) Mediated DNA Vaccines

Jasmine. E. Francis, Ivana Skakic, and Peter. M. Smooker

 

19. Nano-Particulate Platforms for Vaccine Delivery to Enhance Antigen-Specific CD8⁺ T Cell Response

Jhanvi Sharma, Carcia S. Carson, Trevor Douglas, John T. Wilson, and Sebastian Joyce

 

20. PilVax: A Novel Platform for the Development of Mucosal Vaccines

Catherine (Jia-Yun) Tsai, Jacelyn M.S. Loh, and Thomas Proft

 

PART V VACCINE BIOINFORMATICS

21. Bioinformatic Techniques for Vaccine Development: Epitope Prediction and Structural Vaccinology

Peter McCaffrey

 

22. Immunoinformatic Approaches for Vaccine Designing for Pathogens with Unclear Pathogenesis

Naina Arora, Anand K. Keshri, Rimanpreet Kaur, Suraj Singh Rawat, and Amit Prasad

 

23. In silico Identification of the B-cell and T-cell Epitopes of the Antigenic Proteins of Staphylococcus aureus for Potential Vaccines

Sunil Thomas and Irini Doytchinova

 

24. Computational Mining and Characterization of Hypothetical Proteins of Mycobacterium Bovis towards the Identification of Probable Vaccine Candidates

Bhaskar Ganguly

 

25. Recombinant Vaccine Design against Clostridium Spp. Toxins using Immunoinformatics Tools

Rafael Rodrigues Rodrigues, Marcos Roberto Alves Ferreira, Frederico Schmitt Kremer, Rafael Amaral Donassolo, Clóvis Moreira Júnior, Mariliana Luiza Ferreira Alves, and Fabricio Rochedo Conceição

 

26. Searching Epitope-based Vaccines Using Bioinformatic Studies

Marlet Martínez-Archundia, G Lizbeth Ramírez-Salinas, Jazmin García-Machorro

and José Correa-Basurto

 

PART VI VACCINE SAFETY AND REGULATION

27. The Regulatory Evaluation of Vaccines for Human Use

Norman W. Baylor

 

PART VII VACCINE INTELLECTUAL PROPERTY

28. Intellectual Property Rights and Vaccines

Penny Gilbert, Richard Fawcett, Joel Coles, and William Hillson

 

29. Vaccine Intellectual Property

Ana Santos Rutschman, Joshua D. Sarnoff, and Timothy L. Wiemken

 

PART VIII PATHWAYS TO VACCINE COMMERCIALIZATION

30. Resources for Starting a Company

Ann Abraham, Jude Mathew, and Sunil Thomas

 

 

Blurb

This volume provides a practical guide providing step-by-step methods and protocols on vaccine development and production. Divided into three volumes, Volume 3: Resources for Vaccine Development guides readers through chapters on vaccine adjuvants, vaccine vectors, production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation, and intellectual property. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 3: Resources for Vaccine Development aims to be a useful practical guide to researchers to help further their study in this field.